PREFORMULATION AND PHARMACEUTICAL DISPERSION SYSTEMS

Authors

SMITA WASNIK, Assistant professor Valmik Naik College of Pharmacy, Talwadi Tq Kannad Dist, Chhatrapati Sambhaji Nagar (Aurangabad), Maharashtra, Pin - 431003; DR. TUSAR BAJPAI, Assistant Professor, Department Of Chemistry, Hariom Saraswati P. G. College Dhanauri, Haridwar, Uttarakhand, PIN - 247667; DR. SYED AHMED IIZHAR, Professor, Department of Pharmaceutics Sultan Ul Uloom College of Pharmacy, Hyderabad; DR. PRANABESH SIKDAR, Professor, Royal School of Pharmacy, The Assam Royal Global University, Betkuchi, Opp. Tirupati Balaji Temple, NH 37, Guwahati - 781035, Assam, India; MR. HARISH SHARMA, Department of Pharmaceutics Assistant professor Shri Ram College of pharmacy, Banmore, Near Gwalior, 476444

Synopsis

 

Preformulation studies serve as the cornerstone of pharmaceutical development, focusing on the physicochemical characterization of drug candidates to ensure the creation of stable, effective, and safe dosage forms. These investigations assess critical parameters such as solubility, dissolution rate, partition coefficient, polymorphism, and stability, which influence drug performance and compatibility with excipients. Pharmaceutical dispersion systems—such as solid dispersions, emulsions, and suspensions—are employed to enhance the bioavailability of poorly soluble drugs. Techniques like hot-melt extrusion, spray drying, and solvent evaporation are commonly used to formulate amorphous solid dispersions, improving solubility and therapeutic efficacy. Together, preformulation and dispersion strategies enable the rational design of drug delivery systems, optimizing pharmacokinetics and patient outcomes.

 

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Volume

MODERN PHARMACEUTICS

Pages

1-61

Published

July 16, 2025
Copyright (c) 2025 Dr. Avinash Joriya (Volume editor); MS. PRIYANKA RAMKRISHNA NAROTE, MS. AISHWARYA DINKAR GHUGE, MS. HARSHADA RAVINDRA PATIL, DR. RAVINDRA RAGHUNATH MAHAJAN, MAYURI SHATRUGHNA GHADGE, SONAM SONI, DR. S. MOHAMED RABEEK, OMKAR PRAMOD PARAB, CHANDRAKANT DIXITDIXIT, DR. SHUBHASIS DAN, MRS. BHAGYASHRI V. GAWADE, DR. MOIDUL ISLAM JUDDER, MS. PRIYANKA DILIP CHAUDHARI, MS. VRUSHALI BALASAHEB JAGTAP, SHRADDHA DINGARE (Chapter Author); DR. Nidhi Solanki, Sijo Pattam, Sujit Deshmukh (Volume editor); SMITA WASNIK, DR. TUSAR BAJPAI, DR. SYED AHMED IIZHAR, DR. PRANABESH SIKDAR, MR. HARISH SHARMA, RUCHA KAJABAJE, DHANSHRI BORAWAKE, PRIYANKA TODAKARI, SHUBHAM GORE, OMKAR PRAMOD PARAB (Chapter Author)

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How to Cite

WASNIK, S. ., BAJPAI, D. T., IIZHAR, D. S. A., SIKDAR, D. P. ., & SHARMA, M. H. . (2025). PREFORMULATION AND PHARMACEUTICAL DISPERSION SYSTEMS. In D. A. Joriya, D. N. . SOLANKI, S. . Pattam, & S. . DESHMUKH (Eds.), MODERN PHARMACEUTICS (pp. 1-61). Nexus Knowledge Publication (Imprint of AKT Multitask Consultancy). https://nknpub.com/1/catalog/book/9/chapter/26