Nexus Knowledge Publication (Imprint of AKT Multitask Consultancy)
Nexus Publication, the imprint of AKT Multitask Consultancy, is dedicated to publishing insightful and impactful books that cater to both professionals and enthusiasts. Their publications aim to share knowledge, inspire innovation, and foster growth in various fields. Nexus Knowledge Publication is a multidisciplinary, open-access publisher dedicated to advancing scholarly research across a broad spectrum of fields. By emphasizing rapid dissemination of knowledge, Nexus Knowledge Publication ensures swift review and publication processes, allowing researchers to share their findings with the global academic community without delay. Their commitment to open access promotes the free availability of high-quality research, fostering global collaboration and the advancement of knowledge. Why Choose Nexus Knowledge Publication? Multidisciplinary Reach: Nexus Knowledge Publication covers a wide array of disciplines, ensuring that researchers from diverse fields can find a suitable platform for their work. Open Access: All publications are freely accessible to everyone, promoting the dissemination of knowledge without any financial barriers. This encourages greater visibility and citation of published work. Rapid and Peer Review Process: Our efficient and swift review process ensures that your research is published quickly, allowing timely sharing of findings with the global academic community. Global Collaboration: By providing a platform for researchers worldwide, we foster international collaboration and the exchange of ideas, driving innovation and progress in various fields. High-Quality Standards: Our rigorous peer-review process ensures that all published work meets high standards of quality and integrity, enhancing the credibility of our publications. Innovative Solutions: We leverage the latest technology and methodologies to support researchers in publishing and disseminating their work effectively. Comprehensive Support: Our dedicated editorial team provides comprehensive support throughout the publication process, from submission to post-publication, ensuring a smooth and positive experience for our authors. Impactful Research: By focusing on impactful research, we aim to contribute to the advancement of knowledge and the betterment of society.
COMPREHENSIVE APPROACHES TO RESEARCH METHODOLOGY
This textbook provides a definitive and exhaustive guide to the modern landscape of scientific inquiry, designed to serve as a cornerstone resource for graduate students, academic researchers, and professional investigators across disciplines. Adopting a holistic paradigm, the text transcends traditional boundaries by offering an exhaustive exploration of qualitative, quantitative, and mixed-methodological frameworks. It guides the reader systematically from the foundational philosophy of science—examining how epistemological stances shape inquiry—to the practical mechanics of formulating testable hypotheses, executing rigorous sampling strategies, and minimizing systemic biases.
Pedagogy: Educational framework for teaching research design.Triangulation: Combining multiple research methods for validation.Epistemology: Philosophical theory grounding scientific research methods.Scientometrics: Quantitative analysis of scientific literature patterns.Praxis: Translating theoretical research concepts into practice
Copyright (c) 2026 Nexus Knowledge Publication (Imprint of AKT Multitask Consultancy) https://creativecommons.org/licenses/by-nc-nd/4.0
DIABETES MELLITUS PATHOPHYSIOLOGY, PREVENTION, AND PHARMACOLOGICAL MANAGEMENT
This textbook offers a definitive, multi-disciplinary guide to the study of diabetes mellitus, designed specifically for advanced students, clinicians, and medical researchers. It provides an in-depth analysis of the disease, seamlessly bridging cellular pathogenesis with evidence-based clinical practice. The first section details the complex pathophysiology of the disorder, tracing the molecular mechanisms of autoimmune beta-cell destruction in Type 1 diabetes, as well as the genetic and environmental drivers of insulin resistance in Type 2 diabetes. Step-by-step illustrations map out how systemic complications, such as neuropathy, nephropathy, and accelerated cardiovascular disease, develop over time.
Textbook: Comprehensive educational resource on metabolic diseases.Polypharmacy: Managing complex multi-drug regimens safely.Pathogenesis: Cellular and physiological origins of disease.Therapeutics: Clinical application of targeted drug regimens.Glucotoxicity: Cellular damage caused by chronic hyperglycemia
Mrs. Shraddha Hrishikesh Dingare Dingare
This textbook provides a comprehensive and structured exploration of pharmaceutical chemistry, serving as an essential academic and professional resource for understanding drug design and development. It bridges fundamental chemical principles with clinical therapeutic applications, offering a systematic analysis of major drug classes. Each chapter is organized to guide the reader through chemical nomenclature, synthesis pathways, mechanisms of action, and structural modifications that influence biological activity. By detailly mapping structure-activity relationships, the text explains how specific molecular alterations can optimize drug efficacy while reducing toxic side effects.
Monograph: Detailed written study of drug specifications.Chemotherapy: Chemical agents targeting specific diseases.Formulation: Combining active chemicals into usable medication.Assay: Quantitative analysis of drug purity.Stereochemistry: Three-dimensional spatial arrangement of molecules.
ORAL CANCER PATHOLOGY CELLULAR INSIGHTS AND CLINICAL CORRELATES
Oral cancer pathology represents a complex biological spectrum driven by progressive cellular alterations that dictate distinct clinical behaviors. This discipline focuses on the microscopic, genetic, and molecular mechanisms underlying oral squamous cell carcinoma (OSCC), which constitutes the vast majority of oral malignancies. The pathological journey begins with epithelial dysplasia, characterized by cellular atypia, loss of polarity, and increased mitotic figures. Understanding these early cellular insights is vital, as the transition from epithelial atypia to invasive carcinoma involves severe disruption of the basement membrane, cellular architecture, and extracellular matrix. Correlating these cellular phenomena with clinical outcomes is essential for effective patient management, risk stratification, and staging. Histopathological grading examines features like tumor differentiation, depth of invasion, and perineural or lymphovascular space invasion to predict aggressive clinical behavior and nodal metastasis. Furthermore, contemporary oral pathology integrates molecular biomarkers to identify therapeutic targets and predict patient survival rates. By bridging microscopic tissue characteristics with macroscopic clinical presentations, oral cancer pathology provides the diagnostic precision required to guide surgical intervention, select adjuvant therapies, and improve global patient prognosis.
Carcinogenesis: Malignant transformation of oral cells.Dysplasia: Precancerous cellular and architectural changes.Histopathology: Microscopic tissue analysis for diagnosis.Biomarkers: Molecular indicators of tumor behavior.Metastasis: Cellular mechanisms of cancer spread
Pharmacognosy serves as the foundational discipline linking traditional natural remedies with modern pharmaceutical science. This field focuses on the comprehensive study of physical, chemical, biochemical, and biological properties of drugs, drug substances, or potential drugs of natural origin. It encompasses the systematic identification, authentication, cultivation, and processing of crude drugs derived from plants, animals, marine organisms, and microorganisms. By employing rigorous macroscopic, microscopic, and taxonomic evaluation methods, pharmacognosy ensures the quality, safety, purity, and standardization of natural raw materials. Modern pharmacognosy integrates advanced phytochemistry and analytical techniques to isolate, characterize, and quantify bioactive secondary metabolites. These natural compounds—such as alkaloids, glycosides, flavonoids, and terpenoids—often serve as lead structures for novel drug development. Furthermore, the discipline validates traditional ethnomedical knowledge through evidence-based pharmacological screenings. As global interest in herbal medicines, nutraceuticals, and alternative therapies rises, pharmacognosy remains critical for sustainable bioprospecting, preventing drug adulteration, and discovering next-generation therapeutic agents.
Pharmacognosy: Study of natural medicine sources.Phytochemistry: Chemistry of plant-derived chemicals.Crude-drugs: Unrefined natural therapeutic substances.Ethnobotany: Traditional human use of plants.Bioprospecting: Searching nature for new drugs
RESEARCH METHODOLOGY AND MEDICAL STATISTICS
Research methodology and medical statistics form the foundational framework for evidence-based medicine and clinical discovery. This discipline encompasses the systematic design, execution, analysis, and interpretation of medical studies to ensure scientific validity and reproducibility. Key components include defining robust research questions, selecting appropriate study designs—such as randomized controlled trials, cohort studies, and case-control series—and implementing rigorous sampling techniques to minimize selection bias. Medical statistics provides the essential quantitative tools to translate raw clinical data into meaningful medical insights. It guides researchers in hypothesis testing, sample size calculation, data management, and the application of parametric and nonparametric statistical tests. Furthermore, advanced statistical modeling controls for confounding variables, allowing for the precise evaluation of diagnostic tools, treatment efficacies, and epidemiological trends. Mastery of these combined fields is critical for healthcare professionals to critically appraise medical literature, translate clinical data into practice, and advance global health outcomes.
Biostatistics: Statistical applications in medicine.Epidemiology: Study of disease distribution.Methodology: Systematic research design framework.Sampling: Selecting representative study participants.Psychometrics: Measuring psychological and clinical variables.
Professional Communicative English for Nurses
PRECISION ONCOLOGY: Innovations in Diagnosis, Drug Delivery, And Patient Care
Precision oncology represents a transformative approach to cancer care, leveraging molecular profiling, targeted therapies, and personalized treatment strategies to improve patient outcomes. Recent innovations in diagnostic technologies—such as liquid biopsies, next-generation sequencing, and AI-driven imaging—enable earlier and more accurate detection of malignancies. Advances in drug delivery systems, including nanoparticle-based carriers, antibody-drug conjugates, and tumor-targeted platforms, have enhanced therapeutic efficacy while minimizing systemic toxicity. Furthermore, patient-centric care models integrating genomics, digital health tools, and multidisciplinary coordination are reshaping clinical practice. This paper explores the convergence of these innovations, highlighting their impact on treatment personalization, resistance management, and long-term survivorship in oncology.
• Precision oncology • Molecular diagnostics • Targeted therapy • Liquid biopsy • Nanomedicine • Drug delivery systems • Antibody-drug conjugates • Personalized medicine • Cancer genomics • Patient-centered care • AI in oncology • Tumor profiling • Clinical decision support • Oncology innovation • Survivorship care
Copyright (c) 2025 Nexus Knowledge Publication (Imprint of AKT Multitask Consultancy) https://creativecommons.org/licenses/by-nc-nd/4.0
CANCER BIOLOGY AND EMERGING THERAPEUTICS: FROM GENES TO TARGETED THERAPIES
Cancer is a complex and multifactorial disease driven by genetic mutations, epigenetic alterations, and dysregulated cellular pathways. Advances in molecular biology have unraveled the intricate mechanisms underlying tumor initiation, progression, and metastasis, highlighting the roles of oncogenes, tumor suppressor genes, and the tumor microenvironment. These insights have paved the way for the development of emerging therapeutics that move beyond conventional chemotherapy. Targeted therapies, immunotherapies, gene editing technologies, and molecular glues represent a new era of precision medicine, offering improved efficacy and reduced toxicity. This review explores the genetic foundations of cancer and the evolution of therapeutic strategies, emphasizing the integration of multi-omics and personalized approaches to revolutionize cancer treatment.
• Cancer biology • Oncogenes • Tumor suppressor genes • Epigenetics • Targeted therapy • Immunotherapy • Gene therapy • Molecular glues • Precision medicine • Multi-omics • Tumor microenvironment • Signal transduction pathways • CRISPR/Cas9 • Checkpoint inhibitors
CLINICAL LAB EXCELLENCE: Techniques, Tools & Troubleshooting
Clinical Lab Excellence: Techniques, Tools & Troubleshooting is a comprehensive guide designed to empower laboratory professionals with the knowledge and strategies needed to achieve operational excellence in clinical diagnostics. This book bridges foundational principles with cutting-edge innovations, offering a deep dive into the methodologies, instrumentation, and problem-solving frameworks that define high-performing laboratories. Spanning topics from sample integrity and analytical precision to automation, digital integration, and regulatory compliance, each chapter delivers practical insights backed by real-world case studies and expert commentary. Readers will gain a robust understanding of: • Core laboratory techniques and their evolving applications • Selection and optimization of diagnostic tools and technologies • Systematic troubleshooting approaches for common and complex lab challenges • Quality assurance, data management, and workflow efficiency • Human factors, training, and fostering a culture of continuous improvement
Clinical Laboratory Science • Diagnostic Techniques • Laboratory Tools • Troubleshooting Strategies • Quality Control • Laboratory Automation • Molecular Diagnostics
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS
Advanced Biopharmaceutics and Pharmacokinetics explores the dynamic interplay between drug formulation, physiological processes, and mathematical modeling to optimize therapeutic efficacy. This discipline delves into the mechanisms of drug absorption, distribution, metabolism, and excretion (ADME), emphasizing the influence of dosage form design and physicochemical properties on systemic drug exposure. Key topics include compartmental and non-compartmental pharmacokinetic modeling, bioavailability and bioequivalence assessment, modified-release formulations, and in vitro–in vivo correlations (IVIVC). The integration of biopharmaceutical principles with pharmacokinetic data enables rational drug product development, individualized dosing strategies, and regulatory compliance. As biotechnology advances, the scope extends to biopharmaceuticals such as monoclonal antibodies, peptides, and gene therapies, requiring specialized pharmacokinetic considerations. This field serves as a cornerstone for translational research, bridging laboratory insights with clinical outcomes to enhance drug safety, efficacy, and patient-centric care.
Computer-Aided Drug Development (CADD) represents a transformative approach in pharmaceutical research, integrating computational modeling, bioinformatics, and artificial intelligence to streamline the discovery and optimization of therapeutic agents. By simulating molecular interactions and predicting biological activity, CADD significantly reduces the time, cost, and failure rate associated with traditional drug discovery methods. Key methodologies include molecular docking, pharmacophore modeling, quantitative structure-activity relationships (QSAR), and virtual screening, which collectively enable the identification of promising drug candidates with enhanced specificity and safety profiles. Advances in high-performance computing and machine learning have further expanded the capabilities of CADD, allowing for more accurate predictions of ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) properties. This abstract highlights the pivotal role of CADD in modern drug development, its core techniques, and its growing impact on personalized medicine and targeted therapies.
- QSAR (Quantitative Structure-Activity Relationship)
Copyright (c) 2025 Dr. I. Somasundaram, Mr. Praveen Sekar, Ms. Rohini Armo, Dr Bhupen Kumar Baruah (Volume editor); MS. SNNEHAA BHOSLE, NEHA ARORA, MONU KUMAR (MK GROVER), DR. T. DEBORAH PARIPURANAM, DR. AVINASH JORIYA, SANOBER PARVEEN, MR. YOGESH MATTA, MS. DHANASHRI DEVENDRA BORAWAKE, DR. URMILA RAGHUVANSHI, AISHWARYA JHALA, DR. THENRAJA SHANKAR, DR. A JULLIYAN DILLEBAN, MR. GADGE SHUBHAM CHANDRAKANT, DR. LAKSHMI, DR. S. REGHA, DR. VELENTI CHAUHAN, DR. MOIDUL ISLAM JUDDER, DR. MONIKA RAKSE, V. GEETHA, DR. MUKESH KUMAR MEENA, MS. PRAKRITI DIWAN UPADHYAY, DR. RITESH KUMAR, MS. SHRADDHA DINGARE, MS. KHANAPURE PRITI PARMESHWAR, DR. A JULLIYAN DILLEBAN, MS. PRAKRITI DIWAN UPADHYAY, DR. RITESH KUMAR, DR. RESHU TIWARI, Dr VINAY SAGAR VERMA, DR. FARAH DEEBA, MR. SHOUVIK MONDAL, MR. OMPRAKASH B, DR. KAVITHA S PATIL, MAYANDIGARI GURUVAREDDY, DR. JAYASANKAR NARAYANAN (Chapter Author) https://creativecommons.org/licenses/by-nc-nd/4.0
Modern pharmaceutics represents a dynamic and interdisciplinary domain that integrates principles of physical chemistry, biopharmaceutics, pharmacokinetics, and regulatory science to optimize drug formulation and delivery. It encompasses the design, development, and evaluation of dosage forms that ensure therapeutic efficacy, patient compliance, and manufacturing feasibility. With the advent of advanced drug delivery systems, nanotechnology, and personalized medicine, modern pharmaceutics has evolved beyond conventional compounding to embrace precision-targeted therapies and controlled-release mechanisms. Emphasis is placed on preformulation studies, excipient compatibility, stability profiling, and the application of Quality by Design (QbD) and current Good Manufacturing Practices (cGMP). The field also addresses challenges posed by poorly soluble drugs, biologicals, and gene-based therapies, necessitating innovative formulation strategies. As regulatory expectations grow more stringent, modern pharmaceutics plays a pivotal role in bridging scientific innovation with patient-centric healthcare solutions.
Copyright (c) 2025 Dr. Avinash Joriya (Volume editor); MS. PRIYANKA RAMKRISHNA NAROTE, MS. AISHWARYA DINKAR GHUGE, MS. HARSHADA RAVINDRA PATIL, DR. RAVINDRA RAGHUNATH MAHAJAN, MAYURI SHATRUGHNA GHADGE, SONAM SONI, DR. S. MOHAMED RABEEK, OMKAR PRAMOD PARAB, CHANDRAKANT DIXITDIXIT, DR. SHUBHASIS DAN, MRS. BHAGYASHRI V. GAWADE, DR. MOIDUL ISLAM JUDDER, MS. PRIYANKA DILIP CHAUDHARI, MS. VRUSHALI BALASAHEB JAGTAP, SHRADDHA DINGARE (Chapter Author); DR. Nidhi Solanki, Sijo Pattam, Sujit Deshmukh (Volume editor); SMITA WASNIK, DR. TUSAR BAJPAI, DR. SYED AHMED IIZHAR, DR. PRANABESH SIKDAR, MR. HARISH SHARMA, RUCHA KAJABAJE, DHANSHRI BORAWAKE, PRIYANKA TODAKARI, SHUBHAM GORE, OMKAR PRAMOD PARAB (Chapter Author) https://creativecommons.org/licenses/by-nc-nd/4.0
"Advanced Pharmacology – I" is a comprehensive academic resource designed to deepen the understanding of pharmacological principles and their clinical applications. This volume serves as a foundational pillar for postgraduate students, researchers, and healthcare professionals seeking to bridge the gap between experimental pharmacology and evidence-based therapeutics. Structured into thematic modules, the book explores: Mechanisms of drug action at molecular, cellular, and systemic levels Pharmacokinetics and pharmacodynamics with clinical correlations Emerging therapeutic targets in neuropharmacology, cardiovascular, endocrine, and immunopharmacology Advanced drug delivery systems, nanomedicine, and personalized pharmacotherapy Regulatory frameworks, ethical considerations, and translational pharmacology Each chapter integrates recent advances, case-based discussions, and critical analysis of drug safety, efficacy, and rational use. Special emphasis is placed on pharmacovigilance, drug interactions, and therapeutic decision-making in special populations such as pediatrics, geriatrics, and patients with hepatic or renal impairment. By fostering analytical thinking and clinical insight, this book empowers readers to navigate the complexities of modern pharmacology and contribute meaningfully to patient-centered care and drug development.
Copyright (c) 2025 Dr. Avinash Joriya (Volume editor); DR. DHAVAL PATEL, DR. SAKSHAR SAHA, MR. KRISHNENDU RAY, DR. ANURAG RAWAT, DR. SANJEEV KUMAR, DR. RAKESH SAHEBRAO JADHAV, ANSHUL RAM, V. GEETHA, SUJIT RAMCHANDRA DESHMUKH, MAYURI SHATRUGHNA GHADGE, DR. RAKESH SAHEBRAO JADHAV, ARPIT GAWSHINDE, DR. SUMAN SHRIVASTAVA, DR. SAURABH SHRIVASTAVA, DR. SONIA KUKRETI (Chapter Author); Mrs. Nityashree Mohapatra, Ms. Rama Soni, Dr. Keserla Bhavani (Volume editor); MR. LOKESH KUMAR, SUDHANSHU SHANDILYA, DR. G. VENKATA KARTHIK KUMAR REDDY, SHRAVANI PRAKASH PAWAR, DR. JAYANTI TIWARI, LEKHANA PALLAGANI, SOUMYAJIT PANDA, DR. RAKESH SAHEBRAO JADHAV, DR. MOIDUL ISLAM JUDDER, DR. MUKESH KUMAR MEENA (Chapter Author) https://creativecommons.org/licenses/by-nc-nd/4.0
Pharmacology plays a pivotal role in understanding drug interactions, mechanisms, and therapeutic applications. Recent advancements in molecular docking, AI-driven drug discovery, and biomaterials have revolutionized pharmaceutical research. This abstract explores key developments in pharmacokinetics, pharmacodynamics, and targeted drug delivery systems, emphasizing their impact on precision medicine. By integrating computational methodologies and interdisciplinary approaches, pharmacology continues to enhance therapeutic efficacy and patient outcomes.
Pharmacology, Toxicology, Autocoids, Endocrine, Advance Pharmacology
Pathophysiology is the bridge between basic sciences and clinical practice, providing crucial insights into how diseases develop and affect the human body. This book delves into the fundamental mechanisms underlying various pathological conditions, integrating molecular biology, physiology, and clinical manifestations to offer a comprehensive understanding of disease processes. Through systematic exploration, readers will gain knowledge of the disruptions in normal physiological functions, their implications, and the latest advancements in diagnostics and treatment strategies. Designed for students, educators, and healthcare professionals, this book serves as an invaluable resource for enhancing critical thinking and fostering a deeper appreciation of the intricate interplay between health and disease.