ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS

Advanced Biopharmaceutics and Pharmacokinetics explores the dynamic interplay between drug formulation, physiological processes, and mathematical modeling to optimize therapeutic efficacy. This discipline delves into the mechanisms of drug absorption, distribution, metabolism, and excretion (ADME), emphasizing the influence of dosage form design and physicochemical properties on systemic drug exposure. Key topics include compartmental and non-compartmental pharmacokinetic modeling, bioavailability and bioequivalence assessment, modified-release formulations, and in vitro–in vivo correlations (IVIVC). The integration of biopharmaceutical principles with pharmacokinetic data enables rational drug product development, individualized dosing strategies, and regulatory compliance. As biotechnology advances, the scope extends to biopharmaceuticals such as monoclonal antibodies, peptides, and gene therapies, requiring specialized pharmacokinetic considerations. This field serves as a cornerstone for translational research, bridging laboratory insights with clinical outcomes to enhance drug safety, efficacy, and patient-centric care.