AUTOCOID PHARMACOLOGY

Authors

SUJIT RAMCHANDRA DESHMUKH, Graduate Student Pusan National University, South Korea Pin - 46241; MAYURI SHATRUGHNA GHADGE, Msc. Organic chemistry Yashvantrao Chavan Institute of Science Satara, Maharashtra, India Pin - 415019; DR. RAKESH SAHEBRAO JADHAV, Professor & H.O.D. GES's Sir Dr. M.S. Gosavi College of Physiotherapy, India Nashik, Maharashtra; ARPIT GAWSHINDE, Assistant Professor BM College of Pharmaceutical Education and Research, Indore; DR. MUKESH KUMAR MEENA, Assistant Professor Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, 313001

Synopsis

 

Autacoids are biologically active substances that act like local hormones, produced and released by tissues in response to physiological or pathological stimuli. Unlike classical endocrine hormones, autacoids exert their effects near their site of synthesis and are rapidly degraded, ensuring localized action. They play critical roles in inflammation, allergy, pain modulation, vascular tone regulation, and smooth muscle activity.

Major classes of autacoids include:

  • Biogenic amines: Histamine, serotonin
  • Polypeptides: Bradykinin, substance P
  • Lipid-derived mediators: Prostaglandins, leukotrienes, thromboxanes
  • Gaseous mediators: Nitric oxide

Pharmacological modulation of autacoids involves antihistamines, serotonin receptor agonists/antagonists, NSAIDs, and leukotriene inhibitors, which are widely used in treating conditions like asthma, migraines, allergic reactions, peptic ulcers, and cardiovascular disorders.

Understanding autacoid pharmacology is essential for developing targeted therapies that manage localized tissue responses without systemic side effects.

pharmacology

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Volume

ADVANCED PHARMACOLOGY – I

Pages

183-215

Published

July 16, 2025
Copyright (c) 2025 Dr. Avinash Joriya (Volume editor); DR. DHAVAL PATEL, DR. SAKSHAR SAHA, MR. KRISHNENDU RAY, DR. ANURAG RAWAT, DR. SANJEEV KUMAR, DR. RAKESH SAHEBRAO JADHAV, ANSHUL RAM, V. GEETHA, SUJIT RAMCHANDRA DESHMUKH, MAYURI SHATRUGHNA GHADGE, DR. RAKESH SAHEBRAO JADHAV, ARPIT GAWSHINDE, DR. SUMAN SHRIVASTAVA, DR. SAURABH SHRIVASTAVA, DR. SONIA KUKRETI (Chapter Author); Mrs. Nityashree Mohapatra, Ms. Rama Soni, Dr. Keserla Bhavani (Volume editor); MR. LOKESH KUMAR, SUDHANSHU SHANDILYA, DR. G. VENKATA KARTHIK KUMAR REDDY, SHRAVANI PRAKASH PAWAR, DR. JAYANTI TIWARI, LEKHANA PALLAGANI, SOUMYAJIT PANDA, DR. RAKESH SAHEBRAO JADHAV, DR. MOIDUL ISLAM JUDDER, DR. MUKESH KUMAR MEENA (Chapter Author)

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How to Cite

DESHMUKH, S. R. ., GHADGE, M. S., JADHAV, D. R. S. ., GAWSHINDE, A. ., & MEENA, D. M. K. . (2025). AUTOCOID PHARMACOLOGY. In D. A. . Joriya, M. N. . Mohapatra, M. R. . Soni, & D. K. . Bhavani (Eds.), ADVANCED PHARMACOLOGY – I (pp. 183-215). Nexus Knowledge Publication (Imprint of AKT Multitask Consultancy). https://nknpub.com/1/catalog/book/10/chapter/35